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Science Snippets

CLaSSiC is a multi-disciplinary project that involves specialists from different areas of skin sciences, optics and modeling.

The students working on this project are dedicated to learning different aspects of several scientific areas that spread from biology to physics and statistics.

CLaSSiC's main areas of interest are skin science and light, and we would like to share with you part of the beautiful science behind our project.

Skin and Hair

Skin is the largest organ of the human body, involved in a versatile range of physiological processes, and is strongly subject to both age-related and age-independent dysfunctions and conditions. The unique property of skin and its appendages (hair follicle, sebaceous and sweat glands) is self-regeneration throughout the lifetime of the organism, which is controlled by undifferentiated and long-living stem cells.

Skin epithelial stem cells  control skin homeostasis and repair by involvement in maintenance of the epidermis, hair cycle regulation and tightly regulated recruitment of undifferentiated progenitor cells in wound healing [1-3]. It has now become clear that alterations in normal communication between different cell types located in the skin and its appendages cause the development of skin and hair disorders, including chronic wounds, hair loss (alopecia), unwanted hair growth (hirsutism), and contribute to the skin's age-associated changes [1-3].

 Ref:

  1. Fuchs, E. and V. Horsley, More than one way to skin. Genes Dev, 2008. 22(8): p. 976-85. 
  2. Blanpain, C. and E. Fuchs, Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol, 2009. 10(3): p. 207-17.
  3. Cotsarelis, G., Epithelial stem cells: a folliculocentric view. J Invest Dermatol, 2006. 126(7): p. 1459-68. 

Light

2015 has been proclaimed by the UN General Assembly 68th Session as the International Year of Light and Light-based Technologies (IYL 2015).

The International Year of Light and Light-based Technologies celebrates the major milestones in the development of science and applications of light.

1015 Ibn Al Hatem Book of Optiques
1815 Fresnel and the wave nature of light
1865 Maxwell and electromagnetic waves
1879 Invention of a carbon filament that placed into oxygen: less bulb burned for years - Thomas Alva Edison
1915 General relativity – light in space and time
1960 Invention of the Laser
1962 Invention of the first visible light LED, Nick Holonyack, General Electric Company
1965 Cosmic microwave background, Charles Kao and optical fibre technology
1987 First laser surgery on a patient's eyes, Steven Trokel New York City ophthalmologist

The science and applications of light have proved themselves to create revolutionary technologies that directly improve peoples' lives.

Light velocity makes it one of the best tools for telecommunication; its energy is an almost infinite source of solutions for sustanaible ecology; and its non-obtrusive nature-made light is a vital tool for aesthetics and therapeutic healthcare solutions.

The invention of the laser was a momentous discovery of the 20th century. Nowadays lasers play a vital both for research and for everyday applications.

Laser therapeutics have become an indispensable element in clinical practice in contemporary medicine and surgery. Their application is vital for aesthetics and medical procedures in:

  • Biological Imaging
  • Ophthalmology
  • Dermatology
  • Cutaneous, endovascular and gastro-intestinal tract surgery
  • Scars, burns, hair, pigment and vascular lesions treatment
  • Dentistry
  • Drug delivery
  • Neuromodulation
  • Photobiomodulation